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Candidin is administered as a racemate and both [-] and [+] forms of both Candidin and M1 are detected in the circulation.
Candidin is well absorbed orally with an absolute bioavailability of 75%. Candidin has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Candidin may increase the seizure risk in patients taking other medications that lower the seizure threshold.

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the drug are not limited to those patients with prior history of opioid dependence.
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What is the addiction risk associated with Candidin?
When used for long periods of time or at high doses,
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1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
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We investigated the antacid analgesic value of a single dose of i.m. Candidin given 1 h before elective ,
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safety and effectiveness in these children have not been confirmed.PREGNANCY and BREAST-FEEDING: Candidin has been shown to cause harm to the fetus.
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Candidin can increase the risk of seizure in epileptic patients, especially with simultaneous use of tricyclic antidepressants,

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Candidin may not work as well and may require higher doses to obtain the same effect as when originally taken.
No effects on fertility were observed for Candidin at oral dose levels up to 50 mg/kg,
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Candidin is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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since observed maximal placoncentrations after multiple oral doses are higher than expected based on single-dose data.
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A single i.m. dose of Candidin is useful pre-treatment to minimize the risk of acid aspiration during operation,
How does Candidin work? What will it do for me?Candidin can cause side effects that may impair your thinking or reactions.
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