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Hydroxyurea 100 mg was statistically superior to placebo for TOTPAR, SPID, and time of remedication,

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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Hydroxyurea is rapidly and almost completely absorbed after oral administration.
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Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the Hydroxyurea group.
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Tell your doctor or dentist that you take Hydroxyurea before you receive any medical or dental care, emergency care, or surgery.

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Hydroxyurea may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE.
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Hydroxyurea is administered as a racemate and both [-] and [+] forms of both Hydroxyurea and M1 are detected in the circulation.
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Hydroxyurea may increase the seizure risk in patients taking other medications that lower the seizure threshold.
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more potent than Hydroxyurea in producing analgesia and 200 times more potent in ?-opioid binding.
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Hydroxyurea is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions).
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