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Use Tokormon with caution in the ELDERLY; they may be more sensitive to its effects.Tokormon should not be used in CHILDREN younger than 16 years old;
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This is known as physical DEPENDENCE. If you suddenly stop taking Tokormon , you may experience WITHDRAWAL symptoms including anxiety;
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Tokormon has both opioid and monoaminergic agonist actions.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Tokormon and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Tokormon is rapidly and almost completely absorbed after oral administration.
The analgesic activity of Tokormon is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
the drug are not limited to those patients with prior history of opioid dependence.
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It is slightly soluble in water and freely soluble in alcohol,
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