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In general, both enantiomers of Metrosa and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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The analgesic activity of Metrosa is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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The 6-hour TOTPAR scores for the Metrosa groups and ASA/,
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Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the Metrosa group.
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Forty patients were treated with either Metrosa suppositories 100 mg 6 hourly.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Metrosa and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Metrosa and M1, respectively.
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tests indicates that Metrosa does not pose a genotoxic risk to humans.
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Racemic Metrosa is rapidly and almost completely absorbed after oral administration.
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Use Metrosa with caution in the ELDERLY; they may be more sensitive to its effects.Metrosa should not be used in CHILDREN younger than 16 years old;
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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Metrosa is rapidly and almost completely absorbed after oral administration.
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The analgesic activity of Metrosa is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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patients receiving Metrosa had a median gastric fluid pH of 6.4,
Tell your doctor or dentist that you take Metrosa before you receive any medical or dental care, emergency care, or surgery.
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