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It is slightly soluble in water and freely soluble in alcohol,
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions).
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Patryl may rarely be habit forming. Patryl should be avoided in patients with a history.
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than your doctor tells you to.Despite not being labeled habit-forming,
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In general, both enantiomers of Patryl and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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Forty patients were treated with either Patryl suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
In vitro studies indicate that Patryl is unlikely to inhibit,

In vitro studies indicate that Patryl is unlikely to inhibit,
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Patryl has not been shown to cause histamine release. At therapeutic doses, Patryl has no effect on heart rate,
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muscle relaxers) while you are using Patryl ; it may add to their effects.
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Patryl is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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Do not use this medication if you are allergic,
clinical trial was performed to assess the analgesic efficacy and reported side effects of Patryl 100 mg, Patryl 50 mg,
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If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Patryl while you are pregnant.

Patryl can increase the risk of seizure in epileptic patients, especially with simultaneous use of tricyclic antidepressants,
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Patryl has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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Patryl had only slight thermoregulatory effects. Its use is thus unlikely to provoke hypothermia or to facilitate fever.
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Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the Patryl group.
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This is known as physical DEPENDENCE. If you suddenly stop taking Patryl , you may experience WITHDRAWAL symptoms including anxiety;
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