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Anamet has been shown to inhibit reuptake of norepinephrine and serotonin in vitro,
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For Anamet, the following should be considered:The suitability of Anamet suppositories for inclusion in our hospital formulary for the treatment of mild to moderate post-operative pain was evaluated.
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Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the Anamet group.
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since observed maximal placoncentrations after multiple oral doses are higher than expected based on single-dose data.
Anamet is well absorbed orally with an absolute bioavailability of 75%. Anamet has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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There were no other significant respiratory diffences.
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