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clinical trial was performed to assess the analgesic efficacy and reported side effects of Metaxalone 100 mg, Metaxalone 50 mg,
Metaxalone increases the risk of CNS and respiratory depression in these patients.
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Ask your pharmacist if you have questions about which medicines may cause drowsiness.Metaxalone may cause dizziness; alcohol, hot weather, exercise, or fever may increase this effect.
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The analgesic activity of Metaxalone is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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In general, both enantiomers of Metaxalone and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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Metaxalone has been shown to inhibit reuptake of norepinephrine and serotonin in vitro,
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Metaxalone and M1 occurs at two and three hours, respectively, after administration in healthy adults.

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Metaxalone has both opioid and monoaminergic agonist actions.
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Metaxalone may induce psychic and physical dependence of the morphine-type (?- opioid) (See WARNINGS).
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