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The effects of Nipazol and its metabolite mono-O-demethyl-Nipazol,
Use Nipazol with caution in the ELDERLY; they may be more sensitive to its effects.Nipazol should not be used in CHILDREN younger than 16 years old;


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This indicates that Nipazol slightly decreases the precision of thermoregulatory control in addition to reducing the setpoint.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Nipazol and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Nipazol and M1, respectively.
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These mechanisms may contribute independently to the overall analgesic profile of Nipazol.

In general, both enantiomers of Nipazol and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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Some people who use Nipazol for a long time without a break may develop a physical need to continue taking it.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Nipazol and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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Other withdrawal symptoms include unnecessary restlessness of the legs,
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Forty patients were treated with either Nipazol suppositories 100 mg 6 hourly.
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Nipazol may rarely be habit forming. Nipazol should be avoided in patients with a history of opiate addiction or hypersensitivity to opiate medications.
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To prevent it, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of this effect.
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Nipazol is found in breast milk. Do not breast-feed while taking Nipazol .When used for long periods of time or at high doses,
This indicates that Nipazol slightly decreases the precision of thermoregulatory control in addition to reducing the setpoint.
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Ask your pharmacist if you have questions about which medicines may cause drowsiness.Nipazol may cause dizziness; alcohol, hot weather, exercise, or fever may increase this effect.

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Follow your doctor's instructns for recovery.Take this medication exactly as it was prescribed for you.
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For Nipazol, the following should be considered:The suitability of Nipazol suppositories for inclusion in our hospital formulary for the treatment of mild to moderate post-operative pain was evaluated.
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