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Nizole is a centrally acting synthetic opioid analgesic.

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A single i.m. dose of Nizole is useful pre-treatment to minimize the risk of acid aspiration during operation,
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Intramuscular (i.m.) Nizole increases gastric pH during anaesthesia similar to famotidine.
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There were no other significant respiratory diffences.
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The effects of Nizole and its metabolite mono-O-demethyl-Nizole,
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Nizole was not mutagenic in the following assays: Ames Salmonella microsomal activation test,
In general, both enantiomers of Nizole and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
We expected Nizole to be equally effective as our current standard.
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Talk with your doctor if Nizole stops working well. Do not take more than prescribed.Some people who use Nizole for a long time without a break may develop a physical need to continue taking it.
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Nizole is well absorbed orally with an absolute bioavailability of 75%. Nizole has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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This is known as physical DEPENDENCE. If you suddenly stop taking Nizole , you may experience WITHDRAWAL symptoms including anxiety;
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Some people who use Nizole for a long time without a break may develop a physical need to continue taking it.
You may not be able to take Nizole, or you may require a dosage adjustment,
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