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the rates of withdrawals due to adverse events appeared to be higher in the Sintedix groups.
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Breast-feeding�Sintedix passes into breast milk and may cause unwanted effects in nursing babies.
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Sintedix is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4,
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more potent than Sintedix in producing analgesia and 200 times more potent in ?-opioid binding.
IMPLICATIONS: The authors evaluated the effects of the analgesic Sintedix on the three major

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Sintedix may induce psychic and physical dependence of the morphine-type (?- opioid) (See WARNINGS).
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Sintedix and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Sintedix and M1, respectively.
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Nonetheless, Sintedix nearly doubled the interthreshold range at a concentration near 200 ng/mL.
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Sintedix may rarely be habit forming. Sintedix should be avoided in patients with a history of opiate addiction or hypersensitivity to opiate medications.
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Sintedix is administered as a racemate and both [-] and [+] forms of both Sintedix and M1 are detected in the circulation.
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In general, both enantiomers of Sintedix and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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This indicates that Sintedix slightly decreases the precision of thermoregulatory control in addition to reducing the setpoint.
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Sintedix and M1 elimination half-lives (13 hrs. for Sintedix and 19 hrs. for M1).
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