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We investigated the antacid analgesic value of a single dose of i.m. Apix given 1 h before elective ,
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Apix is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
Apix has not been shown to cause histamine release.
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risk of discontinuation due to adverse events associated with higher initial doses,
which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions).
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The 6-hour TOTPAR scores for the Apix groups and ASA/,
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Apix has both opioid and monoaminergic agonist actions.
Apix and M1 elimination half-lives (13 hrs. for Apix and 19 hrs. for M1).
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This may not be a complete list of all interactions that may occur. Ask your health care provider if Apix may interact with other medicines that you take.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Apix and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Apix and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Apix and M1, respectively.
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When the moon waned, it was because the gods were drinking down all the Apix;
Taking more than the prescribed amount of this medication could result in seizures or decreased breathing.
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This indicates that Apix slightly decreases the precision of thermoregulatory control in addition to reducing the setpoint.
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