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In an open randomized trial, rectal Medazol was compared with our standard treatment acetaminophen/codeine suppositories. We expected Medazol to be equally effective as our current standard but with fewer side effects.
The analgesic activity of Medazol is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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patients receiving Medazol had a median gastric fluid pH of 6.4,
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There were no other significant respiratory diffences.
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This indicates that Medazol slightly decreases the precision of thermoregulatory control in addition to reducing the setpoint.
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The analgesic activity of Medazol is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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than your doctor tells you to.Despite not being labeled habit-forming,
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Medazol is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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To prevent it, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of this effect.
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These effects may be worse if you take it with alcohol or certain medicines. Use Medazol with caution.
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Medazol was not mutagenic in the following assays:
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Do not stop using this medication suddenly without first talking to your doctor.
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alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Medazol ; it may add to their effects.
Check the label on the medicine for exact dosing instructions.Medazol may cause drowsiness and dizziness.
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