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Doxazosin has been shown to inhibit reuptake of norepinephrine and serotonin in vitro,
The volume of distribution of Doxazosin was 2.6 and 2.9 liters/kg in male and female subjects, respectively,
The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Doxazosin and M1 occurs at two and three hours, respectively, after administration in healthy adults.

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Doxazosin is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4,

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Doxazosin can impair thinking and the physical abilities required for driving or operating machinery. Doxazosin should be avoided in patients intoxicated with alcohol,
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Prepare for the withdrawal symptoms of discontinued Doxazosin use.
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Follow your doctor's instructns for recovery.Take this medication exactly as it was prescribed for you.
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The product information for Doxazosin states that convulsions have been reported in patients using Doxazosin at the recommended dose levels and that the risk
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Doxazosin was being used with selective serotonin reuptake inhibitors (10 cases),
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In general, both enantiomers of Doxazosin and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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adjustment of the dosing regimen is recommended (see DOSAGE AND ADMINISTRATION).
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