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There were no other significant respiratory diffences.
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Although Metrozole is known to exhibit a local anaesthetic effect, how Metrozole exerts this effect is not understood fully.
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more potent than Metrozole in producing analgesia and 200 times more potent in ?-opioid binding.
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Metrozole has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Metrozole and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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Metrozole may rarely be habit forming. Metrozole should be avoided in patients with a history of opiate addiction or hypersensitivity to opiate medications.
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The analgesic activity of Metrozole is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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clinical trial was performed to assess the analgesic efficacy and reported side effects of Metrozole 100 mg, Metrozole 50 mg,
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Do not use this medication if you are allergic,
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Metrozole may rarely be habit forming. Metrozole should be avoided in patients with a history.
If you think you or someone else may have taken an overdose of Metrozole,
The relative risk of experiencing an episode of nausea under treatment,
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Use Metrozole with caution in the ELDERLY; they may be more sensitive to its effects.Metrozole should not be used in CHILDREN younger than 16 years old;
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whereas Metrozole 50 mg was statistically superior to placebo onlyfor remecation time.
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Nonetheless, Metrozole nearly doubled the interthreshold range at a concentration near 200 ng/mL.
This is known as physical DEPENDENCE. If you suddenly stop taking Metrozole , you may experience WITHDRAWAL symptoms including anxiety;
the rates of withdrawals due to adverse events appeared to be higher in the Metrozole groups.
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adjustment of the dosing regimen is recommended (see DOSAGE AND ADMINISTRATION).
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