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For Hydroxyurea, the following should be considered:The suitability of Hydroxyurea suppositories for inclusion in our hospital formulary for the treatment of mild to moderate post-operative pain was evaluated.

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the rates of withdrawals due to adverse events appeared to be higher in the Hydroxyurea groups.
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Use Hydroxyurea with caution in the ELDERLY; they may be more sensitive to its effects.Hydroxyurea should not be used in CHILDREN younger than 16 years old;
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The analgesic activity of Hydroxyurea is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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Hydroxyurea has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
A single i.m. dose of Hydroxyurea is useful pre-treatment to minimize the risk of acid aspiration during operation,
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the rates of withdrawals due to adverse events appeared to be higher in the Hydroxyurea groups.
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Hydroxyurea may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE.
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Hydroxyurea can impair thinking and the physical abilities required for driving or operating machinery. Hydroxyurea should be avoided in patients intoxicated with alcohol,
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If you think you or someone else may have taken an overdose of Hydroxyurea,
To prevent it, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of this effect.
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Hydroxyurea is associated with craving and tolerance development.
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Hydroxyurea may rarely be habit forming. Hydroxyurea should be avoided in patients with a history.
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Hydroxyurea was what gave the Vedic gods their immortality. It was also a drink for mortals,
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Ask your pharmacist if you have questions about which medicines may cause drowsiness.Hydroxyurea may cause dizziness; alcohol, hot weather, exercise, or fever may increase this effect.
Intramuscular (i.m.) Hydroxyurea increases gastric pH during anaesthesia similar to famotidine.
Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Hydroxyurea is rapidly and almost completely absorbed after oral administration.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions).
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