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Retens is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
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Retens is well absorbed orally with an absolute bioavailability of 75%. Retens has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.

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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Retens and M1 occurs at two and three hours, respectively, after administration in healthy adults.

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The analgesic activity of Retens is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
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This is known as physical DEPENDENCE. If you suddenly stop taking Retens , you may experience WITHDRAWAL symptoms including anxiety;
Ask your health care provider if Retens may interact with other medicines that you take.
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Retens is a centrally acting synthetic opioid analgesic.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions).
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Retens was not mutagenic in the following assays:
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The suitability of Retens suppositories for inclusion in our hospital formulary,
For Retens, the following should be considered:The suitability of Retens.
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Do not use this medication if you are allergic,
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tests indicates that Retens does not pose a genotoxic risk to humans.
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This is known as physical DEPENDENCE. If you suddenly stop taking Retens , you may experience WITHDRAWAL symptoms including anxiety;
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IMPLICATIONS: The authors evaluated the effects of the analgesic Retens on the three major
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