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Mebeverine and M1 elimination half-lives (13 hrs. for Mebeverine and 19 hrs. for M1).
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Mebeverine may not work as well and may require higher doses to obtain the same effect as when originally taken. This is known as TOLERANCE.
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Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the Mebeverine group.
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Mebeverine is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4,

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This is known as physical DEPENDENCE. If you suddenly stop taking Mebeverine , you may experience WITHDRAWAL symptoms including anxiety;
Mebeverine is administered as a racemate and both [-] and [+] forms of both Mebeverine and M1 are detected in the circulation.
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Other withdrawal symptoms include unnecessary restlessness of the legs,
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The volume of distribution of Mebeverine was 2.6 and 2.9 liters/kg in male and female subjects, respectively,
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Mebeverine increases the risk of CNS and respiratory depression in these patients.
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Forty patients were treated with either Mebeverine suppositories 100 mg 6 hourly (qds) or acetaminophen/codeine suppositories 1000/20 mg qds.
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Use Mebeverine with caution in the ELDERLY; they may be more sensitive to its effects.Mebeverine should not be used in CHILDREN younger than 16 years old;
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patients receiving Mebeverine had a median gastric fluid pH of 6.4,
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Mebeverine has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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