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In general, both enantiomers of Zyvox and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.
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Zyvox can increase the risk of seizure in epileptic patients, especially with simultaneous use of tricyclic antidepressants,
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Other withdrawal symptoms include unnecessary restlessness of the legs,
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Zyvox may not work as well and may require higher doses to obtain the same effect as when originally taken.
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the rates of withdrawals due to adverse events appeared to be higher in the Zyvox groups.
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When used for long periods of time or at high doses,
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alcohol or use medicines that may cause drowsiness (eg, sleep aids, muscle relaxers) while you are using Zyvox ; it may add to their effects.
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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Zyvox and M1 occurs at two and three hours, respectively, after administration in healthy adults.
Nalbuphine consumption in the first 24 h after operation was reduced by 35% in the Zyvox group.
Zyvox has not been shown to cause histamine release. At therapeutic doses, Zyvox has no effect on heart rate,
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muscle relaxers) while you are using Zyvox ; it may add to their effects.
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These mechanisms may contribute independently to the overall analgesic profile of Zyvox.
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The binding of Zyvox to human plasma proteins is approximately 20%,
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causing mental or physical dependence.It works in certain areas of the brain and nervous system to decrease pain.
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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Zyvox is rapidly and almost completely absorbed after oral administration.

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Zyvox should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
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This is known as physical DEPENDENCE. If you suddenly stop taking Zyvox , you may experience WITHDRAWAL symptoms including anxiety;
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Respiratory depression should be treated as an overdose.
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Zyvox had only slight thermoregulatory effects. Its use is thus unlikely to provoke hypothermia or to facilitate fever.
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