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In an open randomized trial, rectal Wymox was compared with our standard treatment acetaminophen/codeine suppositories. We expected Wymox to be equally effective as our current standard but with fewer side effects.
The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Wymox and M1 occurs at two and three hours, respectively, after administration in healthy adults.
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1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
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