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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Pepcid and M1 occurs at two and three hours, respectively, after administration in healthy adults.
Pepcid is well absorbed orally with an absolute bioavailability of 75%. Pepcid has a volume of distribution of approximately 2.7 L/kg and is only 20% bound to plasma proteins.
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There were no other significant respiratory diffences.
the manufacturer-sponsored surveillance program's estimated rates of Pepcid abuse in a Pepcid-exposed population.
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The relative risk of experiencing an episode of nausea under treatment,
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Pepcid had only slight thermoregulatory effects. Its use is thus unlikely to provoke hypothermia or to facilitate fever.
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Pepcid should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.
How does Pepcid work? What will it do for me?Pepcid can cause side effects that may impair your thinking or reactions.
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Pepcid and M1 elimination half-lives (13 hrs. for Pepcid and 19 hrs. for M1).
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The analgesic activity of Pepcid is due to both parent drug and the M1 metabolite (see CLINICAL PHARMACOLOGY, Pharmacodynamics).
The product information for Pepcid states that convulsions have been reported in patients using Pepcid at the recommended dose levels and that the risk
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