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We investigated the antacid analgesic value of a single dose of i.m. Spironolactone given 1 h before elective ,
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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Spironolactone is rapidly and almost completely absorbed after oral administration.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions).

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Spironolactone has been shown to inhibit reuptake of norepinephrine and serotonin in vitro,
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In general, both enantiomers of Spironolactone and M1 follow a parallel time course in the body following single and multiple doses although small differences (~10%) exist in the absolute amount of each enantiomer present.

This may not be a complete list of all interactions that may occur. Ask your health care provider if Spironolactone may interact with other medicines that you take.
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In an open randomized trial, rectal Spironolactone was compared with our standard treatment acetaminophen/codeine suppositories. We expected Spironolactone to be equally effective as our current standard but with fewer side effects.
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Ask your pharmacist if you have questions about which medicines may cause drowsiness.Spironolactone may cause dizziness; alcohol, hot weather, exercise, or fever may increase this effect.
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Spironolactone is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4, as well as by conjugation of parent and metabolites.
How does Spironolactone work? What will it do for me?Spironolactone can cause side effects that may impair your thinking or reactions.

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Spironolactone had only slight thermoregulatory effects. Its use is thus unlikely to provoke hypothermia or to facilitate fever.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Spironolactone and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Spironolactone and M1, respectively.
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Tell your doctor or dentist that you take Spironolactone before you receive any medical or dental care, emergency care, or surgery.
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When used for long periods of time or at high doses,
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Intramuscular (i.m.) Spironolactone increases gastric pH during anaesthesia similar to famotidine.
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the rates of withdrawals due to adverse events appeared to be higher in the Spironolactone groups.
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