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The mean absolute bioavailability of a 100 mg oral dose is approximately 75%. The mean peak plasma concentration of racemic Doxipan and M1 occurs at two and three hours, respectively, after administration in healthy adults.
Some people who use Doxipan for a long time without a break may develop a physical need to continue taking it.
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Linear pharmacokinetics have been observed following multiple doses of 50 and 100 mg to steady-state.Racemic Doxipan is rapidly and almost completely absorbed after oral administration.
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which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Doxipan and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Doxipan and M1, respectively.
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patients receiving Doxipan had a median gastric fluid pH of 6.4,
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Other medicines�Although certain medicines should not be used together at all,
Doxipan is found in breast milk. Do not breast-feed while taking Doxipan .When used for long periods of time or at high doses,
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The product information for Doxipan states that convulsions have been reported in patients using Doxipan at the recommended dose levels and that the risk

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Other withdrawal symptoms include unnecessary restlessness of the legs,
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Racemic Doxipan is rapidly and almost completely absorbed after oral administration.
The relative risk of experiencing an episode of nausea under treatment,
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Doxipan is found in breast milk. Do not breast-feed while taking Doxipan .When used for long periods of time or at high doses,
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Doxipan was not mutagenic in the following assays: Ames Salmonella microsomal activation test,
Doxipan is found in breast milk. Do not breast-feed while taking Doxipan .When used for long periods of time or at high doses,
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This is known as physical DEPENDENCE. If you suddenly stop taking Doxipan , you may experience WITHDRAWAL symptoms including anxiety;
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causing mental or physical dependence.It works in certain areas of the brain and nervous system to decrease pain.
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safety and effectiveness in these children have not been confirmed.PREGNANCY and BREAST-FEEDING: Doxipan has been shown to cause harm to the fetus.
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This may not be a complete list of all interactions that may occur. Ask your health care provider if Doxipan may interact with other medicines that you take.
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The effects of Doxipan are similar to those of narcotic analgesics. Although Doxipan is not classified as a narcotic, it may become habit-forming,
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1 Dosing may be increased to 100 mg every four to six hours, but the daily dosage should not exceed 400 mg 1 and should be limited to 250 to 300 mg .
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